Write a Review Ask a Question. Corporate Values. Overview Cardsharing4all has a consumer rating of 1 star from 1 review indicating that most customers are generally dissatisfied with their purchases. View ratings trends. Add media. Top Critical Review. Rating 5 stars 0. Other Verified purchase. Verified site experience. The manuscript further noted a high risk of bias and confounders in almost all the published global longitudinal strain studies.
For all of these reasons, we would recommend great caution in making clinical decisions based on global longitudinal strain changes alone until a clearer evidence base is established. Dexrazoxane Dexrazoxane is an intracellular chelating agent that is believed to interfere with iron-mediated oxygen free radical generation and inhibit topoisomerase II, thereby exerting a cardioprotective effect in the setting of anthracycline administration.
In a paper by Swain et al. The hazard ratio of placebo compared to dexrazoxane was 2. However, concerns over the possible concomitant reduction of the antineoplastic effect of anthracyclines prevented widespread use of dexrazoxane. One of the 2 studies included in the authors' analysis showed a decrease in response rates for dexrazoxane A subsequent meta-analysis of 10 studies 23 confirmed a cardioprotective effect of dexrazoxane relative risk for HF was 0.
Their findings were confirmed in a recent randomized controlled study by Asselin et al. The possibility that dexrazoxane increases the rate of secondary malignancies was raised after a study by Tebbi et al.
Subsequently, Vrooman et al. Patients with pre-existing cardiomyopathy have a high risk for cardiotoxicity, and anthracycline use in this patient population has generally been limited. Dexrazoxane has been used off-label as a cardioprotectant in this setting with some promising results, although large prospective studies are still needed.
In a consecutive case series study, Ganatra et al. Statin Therapy Few studies have evaluated the effect of statin use for the prevention of cardiotoxicity.
A study by Acar et al. The mechanism of this effect is unknown but has been hypothesized to be due to the antioxidant and anti-inflammatory effect of statins. However, widespread evidence for statins for cardioprotection in cancer therapy remains lacking. Conclusion Neurohormonal therapy may attenuate LVEF reduction in patients receiving cardiotoxic chemotherapy; however, these changes appear to be small on short-term follow-up with unclear clinical significance.
Carvedilol has been the best studied, particularly in patients exposed to anthracycline therapy. Metoprolol does not seem to be cardioprotective in patients on anthracyclines with or without trastuzumab. There are not enough data to support the use of one agent over another. Cardioprotective medications appear to be generally well tolerated in the cardio-oncology patient population, and they may decrease chemotherapy interruption, particularly for patients who are receiving trastuzumab.
The trial is expected to begin in approved centers in late or early About 5. The CardiAMP Heart Failure Trial is studying an investigational stem cell-based therapy for heart failure that develops after a heart attack.
The study participants will be randomly placed into one of two groups, a treatment and a sham control group. Neither the patient nor the researcher will know who will be receiving the CardiAMP cell therapy and who will be receiving the sham treatment.
Both groups will be closely monitored throughout the study by a team of physicians and continue to be treated with standard of care medical treatments.
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